refineR version 2.0.0

The new version includes the following updates and improvements:

• Added functionality for verification of reference intervals

• Uncertainty margins estimated for verification of reference intervals can be printed and plotted

• Added green and blue color scheme to the plot function

• RIbench benchmark score: 0.300, Failure rate: 0.0, Implausible Results: 0.069%

refineR version 1.6.2

The new version includes the following updates and improvements:

• Restriction of the search region of lambda to the range 0.0 to 1.0 (before it was 0.0 to 1.5)

• Slight modification of model estimation for small sample sizes (N < 1000)

• Performance improvements, especially for data sets with small sample sizes (N < 1000)

• RIbench benchmark score: 0.300, Failure rate: 0.0, Implausible Results: 0.069%

refineR version 1.6.1

The new version includes the following updates and improvements:

• Revised vignette and literature information

• Slight modification of search region for the fraction of non-pathological samples

• RIbench benchmark score: 0.307, Failure rate: 0.0, Implausible Results: 0.122%

refineR version 1.6.0

The new version includes the following updates and improvements:

• Using the truncated normal distribution now as basic model assumption

• Additional regularization term in cost function to control the fit at the tails of the distribution

• The median bootstrapping model (pointEst=“medianBS”) now corresponds to one parametric model selected from all bootstrapping models

• Some modifications in plot function, e.g. adjusted default xlim

• Slight modification of print function

• RIbench benchmark score: 0.307, Failure rate: 0.0, Implausible Results: 0.122%

refineR version 1.5.1

The new version includes the following updates and improvements:

• Adjusted computation of the roundingBase to now also handle data not rounded to power of 10 (e.g. data that was rounded prior to unit conversion)

• Vignette (‘refineR_package’) demonstrating the main functions of the package

• RIbench benchmark score: 0.307, Failure rate: 0.0, Implausible Results: 0.625%

refineR version 1.5.0

The new version includes the following updates and improvements:

• More fine-grained search region for lambda (lambdaVec)

• Option to use the two-parameter (modified) Box-Cox transformation (findRI(Data = Data, model = "modBoxCox"))

• Update of calculation of costs: new factor to account for small deviations from the assumption of a unimodal distribution of non-pathological samples

• Adapted definition of region of test results that characterizes the non-pathological distribution

• Improved performance for skewed distributions

• RIbench benchmark score: 0.307, Failure rate: 0.0, Implausible Results: 0.625%
  Detailed description can be found in Ammer, T., Ammer, T.,Schuetzenmeister, A., Prokosch, HU., Zierk, J., Rank, C.M., Rauh, M. RIbench: A Proposed Benchmark for the Standardized Evaluation of Indirect Methods for Reference Interval Estimation. Clinical Chemistry (2022)

refineR version 1.0.0

• Initial version put on CRAN

• Detailed description of the method can be found in Ammer, T., Schuetzenmeister, A., Prokosch, HU., Rauh, M., Rank, C.M., Zierk, J. refineR: A Novel Algorithm for Reference Interval Estimation from Real-World Data. Sci Rep 11, 16023 (2021).