High-Performance Open-Source Archive
The Gene Ontology (GO) Consortium <https://geneontology.org/> organizes genes into hierarchical categories based on biological process (BP), molecular function (MF) and cellular component (CC, i.e., subcellular localization). Tools such as 'GoMiner' (see Zeeberg, B.R., Feng, W., Wang, G. et al. (2003) <doi:10.1186/gb-2003-4-4-r28>) can leverage GO to perform ontological analysis of microarray and proteomics studies, typically generating a list of significant functional categories. The significance is traditionally determined by randomizing the input gene list to computing the false discovery rate (FDR) of the enrichment p-value for each category. We explore here the novel alternative of randomizing the GO database rather than the gene list.
| Version: | 1.1 |
| Depends: | R (≥ 4.2.0) |
| Imports: | minimalistGODB, graphics, stats |
| Suggests: | knitr, rmarkdown, testthat (≥ 3.0.0), GO.db |
| Published: | 2026-01-10 |
| DOI: | 10.32614/CRAN.package.randomGODB |
| Author: | Barry Zeeberg [aut, cre] |
| Maintainer: | Barry Zeeberg <barryz2013 at gmail.com> |
| License: | GPL-2 | GPL-3 [expanded from: GPL (≥ 2)] |
| NeedsCompilation: | no |
| CRAN checks: | randomGODB results |
| Reference manual: | randomGODB.html , randomGODB.pdf |
| Vignettes: |
Random GO Database (source) |
| Package source: | randomGODB_1.1.tar.gz |
| Windows binaries: | r-devel: randomGODB_1.1.zip, r-release: randomGODB_1.1.zip, r-oldrel: randomGODB_1.1.zip |
| macOS binaries: | r-release (arm64): randomGODB_1.1.tgz, r-oldrel (arm64): randomGODB_1.1.tgz, r-release (x86_64): randomGODB_1.1.tgz, r-oldrel (x86_64): randomGODB_1.1.tgz |
| Old sources: | randomGODB archive |
| Reverse imports: | GoMiner, HTGM2D, HTGM3D, HTGM4D |
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