n1qn1 6.0.1-14

• As requested by CRAN, gcc-asan and valgrind

• Make package thread-safe: convert global state to thread_local, remove static from local variables in Fortran-translated C code, add integer overflow guards, and fix memory leaks in the R callback wrappers.

• Review all C integer types; confirmed existing types are correct given Fortran ABI constraints (int* required for Fortran INTEGER) and R’s INTEGER() returning int*.

• Fix undefined behavior: add virtual destructor to EvalBase so deleting derived callback objects through a base pointer is well-defined.

• Fix memory leak: validate n and nzm before allocating callback objects, preventing a leak when Rf_error is called on bad inputs.

• Fix restart=TRUE: typo caused mode to remain 2 instead of being set to 3.

• Fix assign=TRUE: wrong field name meant the compressed Hessian was never stored in the supplied environment.

• Add tests for restart, assign, single-variable optimization, repeated calls, and input error conditions.

n1qn1 6.0.1-13

• Make package thread-safe: convert global state to thread_local, remove static from local variables in Fortran-translated C code, add integer overflow guards, and fix memory leaks in the R callback wrappers.

• Review all C integer types; confirmed existing types are correct given Fortran ABI constraints (int* required for Fortran INTEGER) and R’s INTEGER() returning int*.

n1qn1 6.0.1-12

• Add non binary (function pointer) interface/api so that nlmixr2est will not have to be re submitted when changes to this package occur.

n1qn1 6.0.1-11

• Added strict prototype fixes as requested by CRAN

• Added a NEWS.md file to track changes to the package.