ParCC Tutorial Index

ParCC Vignette Library

ParCC (Parameter Converter & Calculator) provides a comprehensive set of tutorials organized by topic. Each vignette includes realistic clinical scenarios, worked examples with R code, and references to the underlying methodology.

Getting Started

vignette("getting-started") – Installation, launching the app, and the Lab Notebook workflow

Core Conversions

vignette("core-conversions") – Rate to Probability, Odds to Probability, and Time Rescaling with real-world examples from the RE-LY trial and UKPDS Risk Engine

Hazard Ratio Conversion (NEW in v1.3.0)

vignette("hr-probability-converter") – Converting control group probabilities to intervention probabilities using Hazard Ratios. Includes worked examples from the PLATO trial (Ticagrelor vs Aspirin) and oncology models.

Survival Extrapolation

vignette("survival-extrapolation") – Fitting Exponential and Weibull survival curves from published Kaplan-Meier data when IPD is unavailable

Background Mortality

vignette("background-mortality") – SMR adjustment, DEALE, Gompertz parameterization, and linear interpolation for adjusting census life tables to disease-specific cohorts

Probabilistic Sensitivity Analysis

vignette("psa-distributions") – Fitting Beta (utilities), Gamma (costs), and LogNormal (HRs) distributions using the Method of Moments. Includes the Rule of 4 approximation.

Economic Evaluation

vignette("economic-evaluation") – ICER calculation, Net Monetary Benefit, and Value-Based Pricing (Headroom Analysis) with Indian HTA context

Batch Processing

vignette("batch-workflow") – Uploading CSV files for bulk conversion, including the new HR-based batch conversion

Key References

Sonnenberg FA, Beck JR. Markov models in medical decision making. Med Decis Making. 1993;13(4):322-338.
Briggs A, Claxton K, Sculpher M. Decision Modelling for Health Economic Evaluation. Oxford University Press; 2006.
Collett D. Modelling Survival Data in Medical Research. 3rd ed. Chapman and Hall/CRC; 2015.
Drummond MF, et al. Methods for the Economic Evaluation of Health Care Programmes. 4th ed. Oxford University Press; 2015.
Cosh E, et al. The value of ‘innovation headroom’. Value in Health. 2007;10(4):312-315.
NICE DSU. Technical Support Document 14: Survival analysis for economic evaluations. 2013.

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