Robust Copy Number Alteration Detection (RCNA) R package RCNA version 1.0 Detects copy number alteration events in targeted exon sequencing data for tumor samples without matched normal controls. The advantage of this method is that it can be applied to smaller sequencing panels including evaluations of exon, transcript, gene, or even user specified genetic regions of interest. Functions in the package include steps for GC-content correction, calculation of quantile based normal karyotype ranges, and calculation of feature score. Cutoffs for "normal" quantile and score are user-adjustable. Software Depends: R (>= 3.5.0) Imports: doParallel, methods, utils, modeest, data.table, foreach, R.utils Suggests: knitr, rmarkdown, usethis Matt Bradley <mbradley@emmes.com> Comprehensive R Archive Network (CRAN) Matt Bradley [aut, cre] GPL-3 2024-12-03 application/tgz https://CRAN.R-project.org/package=RCNA doi:10.32614/CRAN.package.RCNA