Protein Structure Guided Local Test R package POINT version 1.4 Provides an implementation of a rare variant association test that utilizes protein tertiary structure to increase signal and to identify likely causal variants. Performs structure-guided collapsing, which leads to local tests that borrow information from neighboring variants on a protein and that provide association information on a variant-specific level. For details of the implemented method see West, R. M., Lu, W., Rotroff, D. M., Kuenemann, M., Chang, S-M., Wagner M. J., Buse, J. B., Motsinger-Reif, A., Fourches, D., and Tzeng, J-Y. (2019) <doi:10.1371/journal.pcbi.1006722>. Software Depends: methods, stats, rARPACK, Matrix, CompQuadForm Shannon T. Holloway <shannon.t.holloway@gmail.com> Comprehensive R Archive Network (CRAN) Rachel Marceau West [aut], Shannon T. Holloway [aut, cre] GPL-2 2025-05-04 application/tgz https://CRAN.R-project.org/package=POINT doi:10.32614/CRAN.package.POINT