Tools for Performing Pharmacokinetic-Pharmacodynamic Simulations R package PKPDsim version 1.4.1 CRAN Task View: MixedModels (https://CRAN.R-project.org/view=MixedModels) CRAN Task View: Pharmacokinetics (https://CRAN.R-project.org/view=Pharmacokinetics) Simulate dose regimens for pharmacokinetic-pharmacodynamic (PK-PD) models described by differential equation (DE) systems. Simulation using ADVAN-style analytical equations is also supported (Abuhelwa et al. (2015) <doi:10.1016/j.vascn.2015.03.004>). Software Depends: R (>= 4.0.0) Imports: Rcpp (>= 1.0.13), BH, data.table, stringr, MASS, randtoolbox, jsonlite, stats, parallel, magrittr LinkingTo: BH, Rcpp (>= 1.0.13) Suggests: httr, testthat (>= 3.0.0), mockery, knitr, rmarkdown Ron Keizer <ron@insight-rx.com> Comprehensive R Archive Network (CRAN) Ron Keizer [aut, cre], Jasmine Hughes [aut], Dominic Tong [aut], Kara Woo [aut], Jordan Brooks [aut], InsightRX [cph, fnd] MIT + file LICENSE (https://CRAN.R-project.org/package=PKPDsim/LICENSE) 2025-04-17 application/tgz https://CRAN.R-project.org/package=PKPDsim doi:10.32614/CRAN.package.PKPDsim en-US