<?xml version="1.0" encoding="UTF-8"?>
<oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:title>Bayesian Logistic Regression for Oncology Dose-Escalation Trials</dc:title>
  <dc:title>R package OncoBayes2 version 0.9-4</dc:title>
  <dc:subject>CRAN Task View: ClinicalTrials (https://CRAN.R-project.org/view=ClinicalTrials)</dc:subject>
  <dc:description>Bayesian logistic regression model with optional
  EXchangeability-NonEXchangeability parameter modelling for flexible
  borrowing from historical or concurrent data-sources. The safety model
  can guide dose-escalation decisions for adaptive oncology Phase I
  dose-escalation trials which involve an arbitrary number of
  drugs. Please refer to Neuenschwander et al. (2008)
  &lt;doi:10.1002/sim.3230&gt; and Neuenschwander et al. (2016)
  &lt;doi:10.1080/19466315.2016.1174149&gt; for details on the methodology.</dc:description>
  <dc:type>Software</dc:type>
  <dc:relation>Depends: R (&gt;= 3.5.0), RBesT (&gt;= 1.8-0)</dc:relation>
  <dc:relation>Imports: methods, Rcpp (&gt;= 0.12.0), RcppParallel (&gt;= 5.0.1), rstan (&gt;=
2.32.0), rstantools (&gt;= 2.4.0), posterior (&gt;= 1.5.0),
assertthat (&gt;= 0.2.1), checkmate, Formula, bayesplot (&gt;=
1.4.0), ggplot2 (&gt;= 3.0.0), dplyr (&gt;= 1.1.0), tibble, tidyr (&gt;=
1.0.0), abind, scales, rlang (&gt;= 0.3.0), tidyselect, utils,
stats, matrixStats, brms, lifecycle, grDevices</dc:relation>
  <dc:relation>LinkingTo: BH (&gt;= 1.75.0), Rcpp (&gt;= 0.12.0), RcppEigen (&gt;= 0.3.3.3.0),
RcppParallel (&gt;= 5.0.1), rstan (&gt;= 2.32.0), StanHeaders (&gt;=
2.32.0)</dc:relation>
  <dc:relation>Suggests: rmarkdown, knitr, testthat (&gt;= 2.0.0), withr, mvtnorm,
vdiffr, cmdstanr (&gt;= 0.4.0), ragg</dc:relation>
  <dc:creator>Sebastian Weber &lt;sebastian.weber@novartis.com&gt;</dc:creator>
  <dc:publisher>Comprehensive R Archive Network (CRAN)</dc:publisher>
  <dc:contributor>Novartis Pharma AG [cph],
  Sebastian Weber [aut, cre],
  Lukas A. Widmer [aut],
  Andrew Bean [aut],
  Trustees of Columbia University [cph] (R/stanmodels.R, configure,
    configure.win)</dc:contributor>
  <dc:rights>GPL (&gt;= 3)</dc:rights>
  <dc:date>2025-12-18</dc:date>
  <dc:format>application/tgz</dc:format>
  <dc:identifier>https://CRAN.R-project.org/package=OncoBayes2</dc:identifier>
  <dc:identifier>doi:10.32614/CRAN.package.OncoBayes2</dc:identifier>
</oai_dc:dc>
