<?xml version="1.0" encoding="UTF-8"?>
<oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:title>Statistical Methods for Microbiome Compositional Data</dc:title>
  <dc:title>R package MicrobiomeStat version 1.4</dc:title>
  <dc:subject>CRAN Task View: CompositionalData (https://CRAN.R-project.org/view=CompositionalData)</dc:subject>
  <dc:description>A suite of methods for powerful and robust microbiome data analysis addressing zero-inflation, phylogenetic structure and compositional effects. Includes the LinDA method for differential abundance analysis (Zhou et al. (2022)&lt;doi:10.1186/s13059-022-02655-5&gt;), the BMDD (Bimodal Dirichlet Distribution) method for accurate modeling and imputation of zero-inflated microbiome sequencing data (Zhou et al. (2025)&lt;doi:10.1371/journal.pcbi.1013124&gt;) and compositional sparse CCA methods for microbiome multi-omics data integration (Deng et al. (2024) &lt;doi: 10.3389/fgene.2024.1489694&gt;). </dc:description>
  <dc:type>Software</dc:type>
  <dc:relation>Depends: R (&gt;= 3.5.0)</dc:relation>
  <dc:relation>Imports: ggplot2, matrixStats, parallel, stats, utils, Matrix, statmod,
MASS, ggrepel, lmerTest, foreach, modeest, dplyr, Rcpp, mlr3,
mlr3mbo, bbotk, paradox</dc:relation>
  <dc:relation>LinkingTo: Rcpp, RcppArmadillo</dc:relation>
  <dc:relation>Suggests: DiceKriging, randomForest</dc:relation>
  <dc:creator>Jun Chen &lt;chen.jun2@mayo.edu&gt;</dc:creator>
  <dc:publisher>Comprehensive R Archive Network (CRAN)</dc:publisher>
  <dc:contributor>Xianyang Zhang [aut],
  Jun Chen [aut, cre],
  Huijuan Zhou [ctb],
  Linsui Deng [ctb]</dc:contributor>
  <dc:rights>GPL-3</dc:rights>
  <dc:date>2026-03-03</dc:date>
  <dc:format>application/tgz</dc:format>
  <dc:identifier>https://CRAN.R-project.org/package=MicrobiomeStat</dc:identifier>
  <dc:identifier>doi:10.32614/CRAN.package.MicrobiomeStat</dc:identifier>
</oai_dc:dc>
