<?xml version="1.0" encoding="UTF-8"?>
<oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:title>Simulation of Inter-Related Genomic Datasets</dc:title>
  <dc:title>R package InterSIM version 2.3.0</dc:title>
  <dc:description>Generates three inter-related genomic datasets: methylation, gene expression and protein expression having user specified cluster patterns. The simulation utilizes the realistic inter- and intra- relationships from real DNA methylation, mRNA expression and protein expression data from the TCGA ovarian cancer study, Chalise (2016) &lt;doi:10.1016/j.cmpb.2016.02.011&gt;.  </dc:description>
  <dc:type>Software</dc:type>
  <dc:relation>Depends: R (&gt;= 3.5.0), MASS, NMF, tools</dc:relation>
  <dc:creator>Prabhakar Chalise &lt;pchalise@kumc.edu&gt;</dc:creator>
  <dc:publisher>Comprehensive R Archive Network (CRAN)</dc:publisher>
  <dc:contributor>Prabhakar Chalise [aut, cre],
  Rama Raghavan [aut],
  Brooke Fridley [aut]</dc:contributor>
  <dc:rights>GPL</dc:rights>
  <dc:date>2025-01-10</dc:date>
  <dc:format>application/tgz</dc:format>
  <dc:identifier>https://CRAN.R-project.org/package=InterSIM</dc:identifier>
  <dc:identifier>doi:10.32614/CRAN.package.InterSIM</dc:identifier>
</oai_dc:dc>