High-Dimensional Mediation Analysis R package HIMA version 2.3.3 CRAN Task View: CausalInference (https://CRAN.R-project.org/view=CausalInference) CRAN Task View: Epidemiology (https://CRAN.R-project.org/view=Epidemiology) Allows to estimate and test high-dimensional mediation effects based on advanced mediator screening and penalized regression techniques. Methods used in the package refer to Zhang H, Zheng Y, Hou L, Liu L, HIMA: An R Package for High-Dimensional Mediation Analysis. Journal of Data Science. (2025). <doi:10.6339/25-JDS1192>. Software Depends: R (>= 3.5), ncvreg, glmnet Imports: utils, stats, MASS, survival, nlme, HDMT, hdi, conquer, quantreg, hommel, iterators, parallel, foreach, doParallel Suggests: knitr, rmarkdown, testthat Yinan Zheng <y-zheng@northwestern.edu> Comprehensive R Archive Network (CRAN) Yinan Zheng [aut, cre] (ORCID: <https://orcid.org/0000-0002-2006-7320>), Haixiang Zhang [aut], Lifang Hou [aut], Lei Liu [aut, cph] GPL-3 2025-11-17 application/tgz https://CRAN.R-project.org/package=HIMA doi:10.32614/CRAN.package.HIMA