Sample Size Calculation in Hierarchical 2x2 Factorial Trials R package H2x2Factorial version 2.0.0 Implements the sample size methods for hierarchical 2x2 factorial trials under two choices of effect estimands and a series of hypothesis tests proposed in "Sample size calculation in hierarchical 2x2 factorial trials with unequal cluster sizes" (under review), and provides the table and plot generators for the sample size estimations. Software Depends: R (>= 3.6.0) Imports: mvtnorm Suggests: knitr, rmarkdown Zizhong Tian <zizhong.tian@yale.edu> Comprehensive R Archive Network (CRAN) Zizhong Tian [aut, cre], Denise Esserman [aut], Guangyu Tong [aut], Fan Li [aut] LGPL (>= 2.1) 2021-07-23 application/tgz https://CRAN.R-project.org/package=H2x2Factorial doi:10.32614/CRAN.package.H2x2Factorial