<?xml version="1.0" encoding="UTF-8"?>
<oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:title>Estimating Genome-Wide Significance for Whole Genome Sequencing
Studies, Either Single SNP Tests or Region-Based Tests</dc:title>
  <dc:title>R package GWsignif version 1.2.1</dc:title>
  <dc:description>The correlations and linkage disequilibrium between tests can vary as a function of minor allele frequency thresholds used to filter variants, and also varies with different choices of test statistic for region-based tests. Appropriate genome-wide significance thresholds can be estimated empirically through permutation on only a small proportion of the whole genome. </dc:description>
  <dc:type>Software</dc:type>
  <dc:creator>Changjiang Xu &lt;changjiang.h.xu@gmail.com&gt;</dc:creator>
  <dc:publisher>Comprehensive R Archive Network (CRAN)</dc:publisher>
  <dc:contributor>Changjiang Xu [aut, cre],
  Celia M.T. Greenwood [ctb]</dc:contributor>
  <dc:rights>GPL (&gt;= 2)</dc:rights>
  <dc:date>2026-01-21</dc:date>
  <dc:format>application/tgz</dc:format>
  <dc:identifier>https://CRAN.R-project.org/package=GWsignif</dc:identifier>
  <dc:identifier>doi:10.32614/CRAN.package.GWsignif</dc:identifier>
</oai_dc:dc>