Genomic Mediation Analysis with Adaptive Confounding Adjustment R package GMAC version 3.2 Performs genomic mediation analysis with adaptive confounding adjustment (GMAC) proposed by Yang et al. (2017) <doi:10.1101/gr.216754.116>. It implements large scale mediation analysis and adaptively selects potential confounding variables to adjust for each mediation test from a pool of candidate confounders. The package is tailored for but not limited to genomic mediation analysis (e.g., cis-gene mediating trans-gene regulation pattern where an eQTL, its cis-linking gene transcript, and its trans-gene transcript play the roles as treatment, mediator and the outcome, respectively), restricting to scenarios with the presence of cis-association (i.e., treatment-mediator association) and random eQTL (i.e., treatment). Software Depends: parallel Jiebiao Wang <randel.wang@gmail.com> Comprehensive R Archive Network (CRAN) Fan Yang [aut], Jiebiao Wang [aut, cre], Lin Chen [aut] GPL 2025-12-11 application/tgz https://CRAN.R-project.org/package=GMAC doi:10.32614/CRAN.package.GMAC