Predict Drug Functional Similarity to Drug Repurposing R package DrugSim2DR version 0.1.2 A systematic biology tool was developed to repurpose drugs via a drug-drug functional similarity network. 'DrugSim2DR' first predict drug-drug functional similarity in the context of specific disease, and then using the similarity constructed a weighted drug similarity network. Finally, it used a network propagation algorithm on the network to identify drugs with significant target abnormalities as candidate drugs. Software Depends: R (>= 3.6) Imports: igraph, stats, pheatmap, tidyr, reshape2, fastmatch Suggests: knitr, rmarkdown Junwei Han <hanjunwei1981@163.com> Comprehensive R Archive Network (CRAN) Junwei Han [aut, cre, cph], Ji Li [aut], Jiashuo Wu [aut] GPL (>= 2) 2025-10-28 application/tgz https://CRAN.R-project.org/package=DrugSim2DR doi:10.32614/CRAN.package.DrugSim2DR