<?xml version="1.0" encoding="UTF-8"?>
<oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:title>Planning and Analyzing Dose Finding Experiments</dc:title>
  <dc:title>R package DoseFinding version 1.4-1</dc:title>
  <dc:subject>CRAN Task View: ClinicalTrials (https://CRAN.R-project.org/view=ClinicalTrials)</dc:subject>
  <dc:subject>CRAN Task View: ExperimentalDesign (https://CRAN.R-project.org/view=ExperimentalDesign)</dc:subject>
  <dc:description>The DoseFinding package provides functions for the design and analysis
	     of dose-finding experiments (with focus on pharmaceutical Phase
	     II clinical trials). It provides functions for: multiple contrast
	     tests, fitting non-linear dose-response models (using Bayesian and
	     non-Bayesian estimation), calculating optimal designs and an
	     implementation of the MCPMod methodology (Pinheiro et al. (2014)
	     &lt;doi:10.1002/sim.6052&gt;).</dc:description>
  <dc:type>Software</dc:type>
  <dc:relation>Imports: ggplot2, lattice, mvtnorm</dc:relation>
  <dc:relation>Suggests: emmeans, numDeriv, Rsolnp, quadprog, parallel, mmrm,
multcomp, knitr, rmarkdown, MASS, testthat (&gt;= 3.0.0), tibble,
RBesT, nlme, dplyr, tidyr</dc:relation>
  <dc:creator>Marius Thomas &lt;marius.thomas@novartis.com&gt;</dc:creator>
  <dc:publisher>Comprehensive R Archive Network (CRAN)</dc:publisher>
  <dc:contributor>Bjoern Bornkamp [aut] (ORCID: &lt;https://orcid.org/0000-0002-6294-8185&gt;),
  Jose Pinheiro [aut],
  Frank Bretz [aut],
  Ludger Sandig [aut],
  Marius Thomas [aut, cre],
  Daniel Sabanes Bove [aut] (ORCID:
    &lt;https://orcid.org/0000-0002-0176-9239&gt;),
  Novartis Pharma AG [cph, fnd]</dc:contributor>
  <dc:rights>GPL-3</dc:rights>
  <dc:date>2025-07-09</dc:date>
  <dc:format>application/tgz</dc:format>
  <dc:identifier>https://CRAN.R-project.org/package=DoseFinding</dc:identifier>
  <dc:identifier>doi:10.32614/CRAN.package.DoseFinding</dc:identifier>
</oai_dc:dc>
