<?xml version="1.0" encoding="UTF-8"?>
<oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:title>Assurance Methods for Clinical Trials with a Delayed Treatment
Effect</dc:title>
  <dc:title>R package DTEAssurance version 1.1.0</dc:title>
  <dc:description>Provides functions for planning clinical trials subject to a delayed
    treatment effect using assurance-based methods. Includes two 'shiny'
    applications for interactive exploration, simulation, and visualisation of
    trial designs and outcomes. The methodology is described in:
    Salsbury JA, Oakley JE, Julious SA, Hampson LV (2024)
    "Assurance methods for designing a clinical trial with a delayed treatment
    effect" &lt;doi:10.1002/sim.10136&gt;,
    Salsbury JA, Oakley JE, Julious SA, Hampson LV (2024)
    "Adaptive clinical trial design with delayed treatment effects using
    elicited prior distributions" &lt;doi:10.48550/arXiv.2509.07602&gt;.</dc:description>
  <dc:type>Software</dc:type>
  <dc:relation>Depends: R (&gt;= 4.1.0)</dc:relation>
  <dc:relation>Imports: SHELF, shiny, stats, survival, nleqslv, nph, nphRCT, dplyr,
rjags, rpact, magrittr, rlang, future.apply</dc:relation>
  <dc:relation>Suggests: testthat (&gt;= 3.0.0)</dc:relation>
  <dc:creator>James Salsbury &lt;jsalsbury1@sheffield.ac.uk&gt;</dc:creator>
  <dc:publisher>Comprehensive R Archive Network (CRAN)</dc:publisher>
  <dc:contributor>James Salsbury [aut, cre] (ORCID:
    &lt;https://orcid.org/0000-0002-2584-3640&gt;)</dc:contributor>
  <dc:rights>MIT + file LICENSE (https://CRAN.R-project.org/package=DTEAssurance/LICENSE)</dc:rights>
  <dc:date>2025-12-02</dc:date>
  <dc:format>application/tgz</dc:format>
  <dc:identifier>https://CRAN.R-project.org/package=DTEAssurance</dc:identifier>
  <dc:identifier>doi:10.32614/CRAN.package.DTEAssurance</dc:identifier>
</oai_dc:dc>
