<?xml version="1.0" encoding="UTF-8"?>
<oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:title>Drug Repurposing in Cancer via a Subpathway Crosstalk Network</dc:title>
  <dc:title>R package DRviaSPCN version 0.1.5</dc:title>
  <dc:description>A systematic biology tool was developed to repurpose drugs via a subpathway crosstalk network. The operation modes include 1) calculating centrality scores of SPs in the context of gene expression data to reflect the influence of SP crosstalk, 2) evaluating drug-disease reverse association based on disease- and drug-induced SPs weighted by the SP crosstalk, 3) identifying cancer candidate drugs through perturbation analysis. There are also several functions used to visualize the results.</dc:description>
  <dc:type>Software</dc:type>
  <dc:relation>Depends: R (&gt;= 3.6)</dc:relation>
  <dc:relation>Imports: GSVA, clusterProfiler, graphics, igraph, pheatmap, stats</dc:relation>
  <dc:relation>Suggests: rmarkdown, knitr, DT</dc:relation>
  <dc:creator>Junwei Han &lt;hanjunwei1981@163.com&gt;</dc:creator>
  <dc:publisher>Comprehensive R Archive Network (CRAN)</dc:publisher>
  <dc:contributor>Junwei Han [aut, cre, cph],
  Jiashuo Wu [aut]</dc:contributor>
  <dc:rights>GPL (&gt;= 2)</dc:rights>
  <dc:date>2025-01-09</dc:date>
  <dc:format>application/tgz</dc:format>
  <dc:identifier>https://CRAN.R-project.org/package=DRviaSPCN</dc:identifier>
  <dc:identifier>doi:10.32614/CRAN.package.DRviaSPCN</dc:identifier>
</oai_dc:dc>