<?xml version="1.0" encoding="UTF-8"?>
<oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:title>Statistical Functions for the Design of Studies with Composite
Endpoints</dc:title>
  <dc:title>R package CompAREdesign version 2.4.0</dc:title>
  <dc:description>It has been designed to calculate the required sample size in randomized clinical trials with composite endpoints. It also calculates the expected effect and the probability of observing the composite endpoint, among others. The methodology can be found in Bofill &amp; Gómez (2019) &lt;doi:10.1002/sim.8092&gt; and Gómez &amp; Lagakos (2013) &lt;doi:10.1002/sim.5547&gt;. </dc:description>
  <dc:type>Software</dc:type>
  <dc:relation>Imports: stats, utils, copula, ggplot2, ggpubr, rootSolve, numDeriv</dc:relation>
  <dc:relation>Suggests: knitr, rmarkdown</dc:relation>
  <dc:creator>Marta Bofill Roig &lt;marta.bofill.roig@upc.edu&gt;</dc:creator>
  <dc:publisher>Comprehensive R Archive Network (CRAN)</dc:publisher>
  <dc:contributor>Marta Bofill Roig [aut, cre],
  Jordi Cortes Martinez [aut],
  Guadalupe Gomez Melis [ctb]</dc:contributor>
  <dc:rights>GPL-3</dc:rights>
  <dc:date>2025-03-05</dc:date>
  <dc:format>application/tgz</dc:format>
  <dc:identifier>https://CRAN.R-project.org/package=CompAREdesign</dc:identifier>
  <dc:identifier>doi:10.32614/CRAN.package.CompAREdesign</dc:identifier>
</oai_dc:dc>
