Comprehensive Batch Effect Diagnostics and Harmonization R package ComBatFamQC version 1.0.6 Provides a comprehensive framework for batch effect diagnostics, harmonization, and post-harmonization downstream analysis. Features include interactive visualization tools, robust statistical tests, and a range of harmonization techniques. Additionally, 'ComBatFamQC' enables the creation of life-span age trend plots with estimated age-adjusted centiles and facilitates the generation of covariate-corrected residuals for analytical purposes. Methods for harmonization are based on approaches described in Johnson et al., (2007) <doi:10.1093/biostatistics/kxj037>, Beer et al., (2020) <doi:10.1016/j.neuroimage.2020.117129>, Pomponio et al., (2020) <doi:10.1016/j.neuroimage.2019.116450>, and Chen et al., (2021) <doi:10.1002/hbm.25688>. Software Depends: R (>= 4.1.0) Imports: tidyr, dplyr, magrittr, ggplot2, DT, shiny, car, broom, pbkrtest, parallel, Rtsne, MDMR, gamlss, lme4, mgcv, bslib, shinydashboard, methods, gamlss.dist, invgamma, openxlsx Suggests: knitr, rmarkdown, devtools, testthat (>= 3.0.0), remotes, plotly, quarto, spelling, systemfonts, Zheng Ren <zren1422@gmail.com> Comprehensive R Archive Network (CRAN) Zheng Ren [aut, cre, cph] (ORCID: <https://orcid.org/0009-0006-2430-4625>), Andrew Chen [aut, cph] (ORCID: <https://orcid.org/0000-0002-5027-6422>), Elizabeth Horwath [ctb] (ORCID: <https://orcid.org/0009-0009-1224-6984>) MIT + file LICENSE (https://CRAN.R-project.org/package=ComBatFamQC/LICENSE) 2025-03-24 application/tgz https://CRAN.R-project.org/package=ComBatFamQC doi:10.32614/CRAN.package.ComBatFamQC en-US