Pharmacometric Modeling R package Certara.RsNLME version 3.1.1 Facilitate Pharmacokinetic (PK) and Pharmacodynamic (PD) modeling and simulation with powerful tools for Nonlinear Mixed-Effects (NLME) modeling. The package provides access to the same advanced Maximum Likelihood algorithms used by the NLME-Engine in the Phoenix platform. These tools support a range of analyses, from parametric methods to individual and pooled data, and support integrated use within the Pirana pharmacometric workbench <doi:10.1002/psp4.70067>. Execution is supported both locally or on remote machines. Software Depends: R (>= 4.0) Imports: xml2, assertthat, Certara.NLME8 (>= 3.0.2), data.table, jsonlite, methods, utils, ssh Suggests: rlang, knitr, rmarkdown, testthat, magrittr James Craig <james.craig@certara.com> Comprehensive R Archive Network (CRAN) James Craig [aut, cre], Michael Tomashevskiy [aut], Vitalii Nazarov [aut], Shuhua Hu [ctb], Soltanshahi Fred [aut], Certara USA, Inc. [cph, fnd] LGPL-3 2026-03-18 application/tgz https://CRAN.R-project.org/package=Certara.RsNLME doi:10.32614/CRAN.package.Certara.RsNLME