Utilities for Certara's Nonlinear Mixed-Effects Modeling Engine R package Certara.NLME8 version 3.0.2 Perform Nonlinear Mixed-Effects (NLME) Modeling using Certara's NLME-Engine. Access the same Maximum Likelihood engines used in the Phoenix platform, including algorithms for parametric methods, individual, and pooled data analysis. The Quasi-Random Parametric Expectation-Maximization Method (QRPEM) is also supported <https://www.page-meeting.org/default.asp?abstract=2338>. Execution is supported both locally or on remote machines. Remote execution includes support for Linux Sun Grid Engine (SGE), Simple Linux Utility for Resource Management (SLURM) grids, Linux and Windows multicore, and individual runs. Software Depends: R (>= 4.0.0) Imports: xml2, batchtools (>= 0.9.9), reshape, utils, data.table Suggests: testthat James Craig <james.craig@certara.com> Comprehensive R Archive Network (CRAN) Soltanshahi Fred [aut], Michael Tomashevskiy [aut], James Craig [aut, cre], Shuhua Hu [ctb], Certara USA, Inc. [cph, fnd] LGPL-3 2025-08-20 application/tgz https://CRAN.R-project.org/package=Certara.NLME8 doi:10.32614/CRAN.package.Certara.NLME8