Clustering of Genomic Regions Analysis Method R package CREAM version 1.1.1 Provides a new method for identification of clusters of genomic regions within chromosomes. Primarily, it is used for calling clusters of cis-regulatory elements (COREs). 'CREAM' uses genome-wide maps of genomic regions in the tissue or cell type of interest, such as those generated from chromatin-based assays including DNaseI, ATAC or ChIP-Seq. 'CREAM' considers proximity of the elements within chromosomes of a given sample to identify COREs in the following steps: 1) It identifies window size or the maximum allowed distance between the elements within each CORE, 2) It identifies number of elements which should be clustered as a CORE, 3) It calls COREs, 4) It filters the COREs with lowest order which does not pass the threshold considered in the approach. Software Depends: R (>= 3.3) Imports: stats, utils Suggests: testthat Benjamin Haibe-Kains <benjamin.haibe.kains@utoronto.ca> Comprehensive R Archive Network (CRAN) Seyed Ali Madani Tonekaboni [aut], Victor Kofia [aut], Mathieu Lupien [aut], Benjamin Haibe-Kains [aut, cre] GPL (>= 3) 2018-06-06 application/tgz https://CRAN.R-project.org/package=CREAM doi:10.32614/CRAN.package.CREAM