Case-Cotrol Analysis of Multi-Allelic Loci R package BIGDAWG version 3.1.0 Data sets and functions for chi-squared Hardy-Weinberg and case-control association tests of highly polymorphic genetic data [e.g., human leukocyte antigen (HLA) data]. Performs association tests at multiple levels of polymorphism (haplotype, locus and HLA amino-acids) as described in Pappas DJ, Marin W, Hollenbach JA, Mack SJ (2016) <doi:10.1016/j.humimm.2015.12.006>. Combines rare variants to a common class to account for sparse cells in tables as described by Hollenbach JA, Mack SJ, Thomson G, Gourraud PA (2012) <doi:10.1007/978-1-61779-842-9_14>. Software Depends: R (>= 4.0.0) Imports: XML, haplo.stats, parallel Suggests: knitr, rmarkdown Steve Mack <Steven.Mack@ucsf.edu> Comprehensive R Archive Network (CRAN) Derek Pappas [aut], Livia Tran [aut], Steve Mack [aut, cre], Jill Hollenbach [aut] GPL (>= 3) 2026-04-30 application/tgz https://CRAN.R-project.org/package=BIGDAWG doi:10.32614/CRAN.package.BIGDAWG