Utilities for the Application of a Polygenic Score to a VCF R package ApplyPolygenicScore version 4.0.2 Simple and transparent parsing of genotype/dosage data from an input Variant Call Format (VCF) file, matching of genotype coordinates to the component Single Nucleotide Polymorphisms (SNPs) of an existing polygenic score (PGS), and application of SNP weights to dosages for the calculation of a polygenic score for each individual in accordance with the additive weighted sum of dosages model. Methods are designed in reference to best practices described by Collister, Liu, and Clifton (2022) <doi:10.3389/fgene.2022.818574>. Software Depends: R (>= 4.2.0) Imports: vcfR, pROC, data.table, BoutrosLab.plotting.general, lattice Suggests: knitr, rmarkdown, scales, testthat (>= 3.0.0) Paul Boutros <PBoutros@sbpdiscovery.org> Comprehensive R Archive Network (CRAN) Paul Boutros [cre], Nicole Zeltser [aut] (ORCID: <https://orcid.org/0000-0001-7246-2771>), Rachel Dang [ctb], Raag Agrawal [ctb] GPL-2 2026-02-26 application/tgz https://CRAN.R-project.org/package=ApplyPolygenicScore doi:10.32614/CRAN.package.ApplyPolygenicScore