Package: admixr2
Type: Package
Title: Aggregate Data Modelling
Version: 0.1.0
Authors@R: c(
        person("H.", "van de Beek", email = "h.van.de.beek@lacdr.leidenuniv.nl", role = c("aut", "cre")),
        person("P.A.J.", "Välitalo", role = "aut"),
        person("L.B.", "Zwep", role = "aut"),
        person("J.G.C.", "van Hasselt", role = "aut")
    )
Description: Fit pharmacokinetic/pharmacodynamic (PK/PD) models to aggregate-level data (mean vector
    and covariance matrix per study) rather than individual-level data. Integrates
    with the 'nlmixr2'/'rxode2' ecosystem via three estimation methods: a First-Order ('FO')
    analytical estimator, a Monte Carlo (MC) estimator, and an Iterative Reweighting
    Monte Carlo ('IRMC') estimator. Methods are
    based on Välitalo (2021) <doi:10.1007/s10928-021-09760-1>; software described in
    van de Beek et al. (2025) <doi:10.1007/s10928-025-10011-w>.
License: GPL (>= 3)
URL: https://leidenpharmacology.github.io/admixr2/,
        https://github.com/LeidenPharmacology/admixr2
BugReports: https://github.com/LeidenPharmacology/admixr2/issues
Encoding: UTF-8
LazyData: true
Depends: R (>= 4.1.0)
RoxygenNote: 7.3.3
Imports: checkmate, digest, nlmixr2est, nloptr, qs2, randtoolbox, Rcpp,
        rxode2
LinkingTo: Rcpp, RcppEigen
Suggests: expm, furrr, future, ggplot2, knitr, mnormt, nlmixr2,
        patchwork, rmarkdown, testthat (>= 3.0.0)
VignetteBuilder: knitr
Config/testthat/edition: 3
NeedsCompilation: yes
Packaged: 2026-05-29 13:52:39 UTC; hidde
Author: H. van de Beek [aut, cre],
  P.A.J. Välitalo [aut],
  L.B. Zwep [aut],
  J.G.C. van Hasselt [aut]
Maintainer: H. van de Beek <h.van.de.beek@lacdr.leidenuniv.nl>
Repository: CRAN
Date/Publication: 2026-06-02 10:50:02 UTC
Built: R 4.5.2; x86_64-apple-darwin20; 2026-06-02 12:50:08 UTC; unix
Archs: admixr2.so.dSYM
